SET: SET domain
| PAG Title | SET: SET domain |
| PAG ID | PEX000769 |
| Type | A |
| Source Link |  Pfam |
| Publication Reference | NA |
| PAG Description | SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases) 2. A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction 3. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure 5. |
| Species | Homo sapiens |
| nCoCo Score | 0 |
| Base PAG ID | PEX000769 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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